Assay of Plasma Insulin in Human Subjects by Immunological Methods

@article{Yalow1959AssayOP,
  title={Assay of Plasma Insulin in Human Subjects by Immunological Methods},
  author={Rosalyn Sussman Yalow and S A Berson},
  journal={Nature},
  year={1959},
  volume={184},
  pages={1648-1649}
}
WE have previously reported on the immuno-assay of beef insulin and certain other animal insulins, employing antiserums from human subjects treated with commercial mixtures of beef and pork insulin1. The insulin-binding antibodies present in these anti-serums do not form precipitable complexes with insulin, but with the use of insulin labelled with iodine-131 the complexes are readily demonstrable by paper chromatography and electrophoresis2. Beef, pork, sheep and horse insulins can be assayed… CONTINUE READING
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