Assay for peptidoglycan O-acetyltransferase: a potential new antibacterial target.

  title={Assay for peptidoglycan O-acetyltransferase: a potential new antibacterial target.},
  author={Patrick J Moynihan and Anthony J Clarke},
  journal={Analytical biochemistry},
  volume={439 2},
The O-acetylation of peptidoglycan occurs at the C-6 hydroxyl group of muramoyl residues in many human pathogens, both gram positive and gram negative, such as Staphylococcus aureus and species of Campylobacter, Helicobacter, Neisseria, and Bacillus, including Bacillus anthracis. The process is a maturation event being catalyzed either by integral membrane O-acetylpeptidoglycan transferase (Oat) of gram-positive bacteria or by a two-component peptidoglycan O-acetyltransferase system (PatA/PatB… CONTINUE READING
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