Assay for human matrix gla protein in serum: potential applications in the cardiovascular field.

@article{Braam2000AssayFH,
  title={Assay for human matrix gla protein in serum: potential applications in the cardiovascular field.},
  author={Lavienja A. J. L. M. Braam and Paul Dissel and Barbara Gijsbers and Henri M. H. Spronk and Karly Hamul{\'y}ak and Berry A. M. Soute and W. M. H. Debie and Cees Vermeer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 5},
  pages={1257-61}
}
Matrix Gla protein (MGP) is synthesized in a vitamin K-dependent way in smooth muscle cells of the healthy vessel wall, and its mRNA transcription is substantially upregulated in atherosclerotic lesions. Here we report the preparation of a monoclonal antibody against human MGP and its use in an enzyme-linked immunosorbent assay. The intra-assay and interassay coefficients of variation in serum samples were 5.4% and 12.6%, respectively, and the lower detection limit was 8.5% of the normal serum… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome

  • PB Munroe, RO Olgenturk, +5 authors E. Chung
  • Nat Genet
  • 1999

Nutritional intake of vitamins K-1 (phylloquinone) and K-2 (menaquinone) in The Netherlands

  • LJ Schurgers, JM Geleijnse, +4 authors C. Vermeer
  • J Nutr Environ Med
  • 1999

Serum undercar - boxylated osteocalcin is a marker of the risk of hip fracture : a three year follow - up study

  • P Szulc, Chapuy M-C, PJ Meunier, PD Delmas
  • Bone
  • 1996

Similar Papers

Loading similar papers…