Asprosin, a Fasting-Induced Glucogenic Protein Hormone

  title={Asprosin, a Fasting-Induced Glucogenic Protein Hormone},
  author={Chase Romere and Clemens Duerrschmid and Juan C Bournat and Petra Constable and Mahim Jain and Fan Xia and Pradip Kumar Saha and Maria Del Solar and Bokai Zhu and Brian R. York and Poonam Sarkar and David A. Rendon and M. Waleed Gaber and Scott A Lemaire and Joseph S. Coselli and Dianna Milewicz and Vivien Sutton and Nancy F Butte and David D. Moore and Atul R. Chopra},
Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G… CONTINUE READING


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