Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation.

@article{Kebir2007AspirintriggeredLO,
  title={Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation.},
  author={Driss El Kebir and Levente J{\'o}zsef and Tarek Khreiss and Wanling Pan and Nicos A Petasis and Charles N Serhan and J{\'a}nos G. Filep},
  journal={Journal of immunology},
  year={2007},
  volume={179 1},
  pages={616-22}
}
Elevated plasma levels of the acute-phase reactant serum amyloid A (SAA) have been used as a marker and predictor of inflammatory diseases. SAA regulates leukocyte activation; however, it is not known whether it also modulates neutrophil apoptosis, which is critical to the optimal expression and resolution of inflammation. Culture of human neutrophils with SAA (0.1-20 microg/ml) markedly prolonged neutrophil longevity by delaying constitutive apoptosis. SAA evoked concurrent activation of the… CONTINUE READING

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