Aspirin prevention of cholesterol gallstone formation in prairie dogs.

@article{Lee1981AspirinPO,
  title={Aspirin prevention of cholesterol gallstone formation in prairie dogs.},
  author={S. P. Lee and Martin C. Carey and J. Thomas Lamont},
  journal={Science},
  year={1981},
  volume={211 4489},
  pages={
          1429-31
        }
}
When prairie dogs (Cynomys ludovicianus) are fed a diet containing cholesterol, a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile. Gelation of mucin precedes the precipitation of cholesterol liquid and solid crystals and the development of gallstones. Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile. This… 
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Role of gallbladder mucus in the pathogenesis of cholesterol gallstones.
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The results allow proposing a novel hypothesis and concept of cholesterol gallstone pathogenesis in man: cholestanol may be responsible for the cholesterol supersaturation of gallbladder bile,…
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Although cholesterol feeding did not appear to alter smooth muscle contractility in the guinea pig gallbladder, it caused significant gallbladders enlargement by a mechanism which may be dependent on prostaglandins.
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Cholesterol cholelithiasis in the prairie dog: Role of mucin and nonmucin glycoproteins
TLDR
The increased biliary glycoprotein level in cholesterolfed, prostaglandin E1‐treated prairie dogs, which reflects higher levels of mucin and nonmucin glycoproteins, appears to be an important factor in gallstone formation.
Ground squirrel model for cholelithiasis: Role of epithelial glycoproteins
TLDR
The results indicate that mucin hypersecretion appears to be more closely related to the initiation of nucleation than does either bile calcium or pH, which is typically seen in other regions of the gastrointestinal tract where sialomucins predominate during pathologic processes.
Role of Gallbladder Mucin in Pathophysiology of Gallstones
TLDR
It is suggested that inhibition of mucin release may prevent cholesterol stone formation during high‐risk periods or after dissolution therapy with bile salts.
Cyclic nucleotides and glycoproteins during formation of cholesterol gallstones in prairie dogs
Increased biliary protein precedes gallstone formation
TLDR
The finding that gallbladder bile total protein increases during crystal agglomeration indicates that high concentrations of biliary total protein in combination with elevated levels of calcium may promote cholesterol crystal nucleation and gallstone formation.
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TLDR
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TLDR
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