Aspirin ototoxicity in the guinea pig.

  title={Aspirin ototoxicity in the guinea pig.},
  author={S. Crif{\`o}},
  journal={ORL; journal for oto-rhino-laryngology and its related specialties},
  volume={37 1},
  • S. Crifò
  • Published 1975 in
    ORL; journal for oto-rhino-laryngology and its…
Aspirin ototoxicity has been studied on guinea pigs by shiver-audiometry and histological investigation of the cochlear duct. One dose of 350 mg/kg has provoked, after 7 h, a mean hearing loss of 18-24 dB at 0.25-8 kHz, followed by complete recovery in 3 days. The difference between the administration of 50 mg/kg/day and 350 mg/kg/day consists of a wide extension of the frequencies involved, and in about 10 dB a greater hearing loss. In both cases, no appreciable recovery of hearing was… CONTINUE READING