Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts.

@article{Mifflin2004AspirinmediatedCT,
  title={Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts.},
  author={Randy C. Mifflin and Jamal I. Saada and John F di Mari and John D Valentich and Patrick A. Adegboyega and Don W. Powell},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 2},
  pages={470-8}
}
Acetylsalicylic acid (aspirin) is a cyclooxygenase (COX) inhibitor, yet some of its therapeutic effects are thought to derive from mechanisms unrelated to prostaglandin synthesis inhibition. In human intestinal myofibroblasts, aspirin, at therapeutic doses, had the unexpected effect of inducing prolonged COX-2 expression. This induction was especially pronounced when cells were treated with interleukin-1alpha (IL-1) plus aspirin for 24 h. Sodium salicylate, a poor COX inhibitor, likewise… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…