Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy

@inproceedings{Ming2017AspirinIT,
  title={Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy},
  author={Jianguang Ming and Bo Sun and Ziwei Li and Lin Lin and Xiangqi Meng and Bo Han and Ruijia Wang and Pengfei Wu and Jianlong Li and Jinquan Cai and Chuanlu Jiang},
  booktitle={Aging},
  year={2017}
}
Aberrant activation of sonic hedgehog (SHH)/glioma-associated oncogene homolog 1 (GLI1) pathway plays an important role in the tumorigenicity of malignant glioma cells and resistance to temozolomide (TMZ). Here we investigated the aspirin's antineoplastic molecular route by targeting SHH/GLI1 pathway and examined the feasibility of aspirin combined with TMZ therapy. Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) revealed that the activity of the SHH/GLI1 pathway was… CONTINUE READING
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