Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans.

@article{Ayyadevara2013AspirinIO,
  title={Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans.},
  author={Srinivas Ayyadevara and Puneet Bharill and Abhijit Dandapat and Chang-ping Hu and Magomed Khaidakov and Sona Mitra and Robert Joseph Shmookler Reis and Jawahar Lal Mehta},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={18 5},
  pages={481-90}
}
AIMS Oxidative stress and inflammation are leading risk factors for age-associated functional declines. We assessed aspirin effects on endogenous oxidative-stress levels, lifespan, and age-related functional declines, in the nematode Caenorhabditis elegans. RESULTS Both aspirin and its salicylate moiety, at nontoxic concentrations (0.5-1 mM), attenuated endogenous levels of reactive oxygen species (p<0.001), and upregulated antioxidant genes encoding superoxide dismutases (especially sod-3, p… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
22 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…