Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies.

@article{DunoyerGeindre2004AspirinIE,
  title={Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies.},
  author={Sylvie Dunoyer-Geindre and Egbert K. O. Kruithof and Françoise Boehlen and N Satta-Poschung and Guido Reber and Philippe de Moerloose},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2004},
  volume={2 7},
  pages={1176-81}
}
BACKGROUND Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitro, as documented by an increased expression of tissue factor as well as leukocyte adhesion molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin. Currently, treatment of patients with the antiphospholipid syndrome includes aspirin, particularly for women with recurrent fetal loss. OBJECTIVE The present study was undertaken to… CONTINUE READING