Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro.

@article{Yang2008AspirinIC,
  title={Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro.},
  author={Lifeng Yang and Xiangmei Zhou and Jianmin Yang and Xiaomin Yin and Lifang Han and Deming Zhao},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={199 1-2},
  pages={10-7}
}
The synthetic peptide consisting of amino acid residues 106-126 of the human prion protein PrP106-126 has been demonstrated to generate fibrils, which damage neurons either directly by interacting with components of the cell surface to trigger cell apoptosis signaling or indirectly by activating microglia to produce inflammatory mediators. In our study, rat microglia cells were treated with PrP106-126 or scramble PrP106-126 (Scr PrP). Activated nuclear factor kappaB (NF-kappaB) was determined… CONTINUE READING