Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 angstroms resolution.

Abstract

Phospholipase A2 is potentially an important target for structure-based rational drug design. In order to determine the involvement of phospholipase A2 in the action of non-steroidal anti-inflammatory drugs (NSAIDs), the crystal structure of the complex formed between phospholipase A2 and aspirin has been determined at 1.9 angstroms resolution. The… (More)

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@article{Singh2005AspirinII, title={Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 angstroms resolution.}, author={Rajendra Kumar Singh and Abdul Samarth Ethayathulla and Talat Jabeen and Sujata Sharma and Punit Kaur and Tej P Singh}, journal={Journal of drug targeting}, year={2005}, volume={13 2}, pages={113-9} }