Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT.

@article{Park2010AspirinIA,
  title={Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT.},
  author={I. Park and Jeong-Rang Jo and Hua Hong and Ki-Young Nam and Jong-Bae Kim and Sang-Hee Hwang and Mi-Sun Choi and Nam-Hee Ryu and Hyeji Jang and Sang-Han Lee and Chin-Soo Kim and Tae-Geon Kwon and Gy-Young Park and Jong-Wook Park and Byeong-Churl Jang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 3},
  pages={713-20}
}
NSAIDs and COX-2 inhibitors show anti-cancer activities in many cancer cells. In this study, we investigated the effects of NSAIDs (aspirin or indomethacin) and COX-2 inhibitor (NS-398) on growth of YD-8 human oral squamous carcinoma cells. Interestingly, among drugs tested, aspirin showed strongest inhibitory effects on viability and survival of YD-8 cells. Profoundly, aspirin treatment resulted in severe cell shrinkage and nuclear DNA fragmentation in YD-8 cells, suggesting the aspirin… CONTINUE READING

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