Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations.

@article{Szczeklik1976AspirininducedAH,
  title={Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations.},
  author={Andrzej Szczeklik and Ryszard Jerzy Gryglewski and Grazyna Czerniawska-Mysik and A. Żmuda},
  journal={The Journal of allergy and clinical immunology},
  year={1976},
  volume={58 1 PT 1},
  pages={10-8}
}
Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene. Low doses of the first three drugs induced bronchoconstriction in all the patients as evidenced by fall in peak expiratory flow and appearance of clinical symptoms. There were no reactions to therapeutic doses of dextropropoxyphene. Aspirin, fenoprofen, and ibuprofen, but not dextropropoxyphene, inhibited prostaglandin synthetase… CONTINUE READING
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