Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes.

BACKGROUND Aspirin-induced asthma (AIA) affects one in 10 individuals with adult-onset asthma. It is not known if aspirin sensitivity is due to immune mechanisms or to interference with biochemical pathways. OBJECTIVE The study aimed to test for possible involvement of the genes of the Major Histocompatibility Complex (MHC) in AIA. METHODS HLA-DPB1 and… CONTINUE READING