Aspirin increases blood alcohol concentrations in humans after ingestion of ethanol.

  title={Aspirin increases blood alcohol concentrations in humans after ingestion of ethanol.},
  author={R. Roine and R. Thomas Gentry and Rolando Hern{\'a}ndez-Mu{\~n}oz and Enrique Baraona and Charles S. Lieber},
  volume={264 18},
Gastric first-pass metabolism of ethanol is an important determinant of blood alcohol concentrations. We studied five healthy volunteers after ingestion of ethanol (0.3 g/kg of body weight) and found that blood alcohol concentrations in the fed state (ie, 1 hour after a standard breakfast) were significantly higher when the subjects received 1 g of aspirin 1 hour before ingestion of ethanol than without the drug. In vitro, aspirin clearly decreased the activity of gastric alcohol dehydrogenase… CONTINUE READING

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