Aspirin in the primary prevention of angina pectoris in a randomized trial of United States physicians.

@article{Manson1990AspirinIT,
  title={Aspirin in the primary prevention of angina pectoris in a randomized trial of United States physicians.},
  author={Joann E. Manson and Diederick E. Grobbee and Meir Jonathan Stampfer and James O Taylor and Samuel Z. Goldhaber and J. Michael Gaziano and Paul M. Ridker and Julie E. Buring and Charles H. Hennekens},
  journal={The American journal of medicine},
  year={1990},
  volume={89 6},
  pages={772-6}
}
PURPOSE The objective of this study was to examine the effect of low-dose aspirin (325 mg on alternate days) on the primary prevention of angina pectoris in the United States Physicians' Health Study. Despite a postulated role of platelets in atherogenesis and myocardial ischemia, the effect of chronic platelet inhibition on the development of clinical angina pectoris is unknown. SUBJECTS AND METHODS The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial among 22… CONTINUE READING