Aspirin for the Prophylaxis of Venous Thromboembolic Events in Orthopedic Surgery Patients: A Comparison of the AAOS and ACCP Guidelines with Review of the Evidence

@article{Stewart2013AspirinFT,
  title={Aspirin for the Prophylaxis of Venous Thromboembolic Events in Orthopedic Surgery Patients: A Comparison of the AAOS and ACCP Guidelines with Review of the Evidence},
  author={David W. Stewart and Jessica E. Freshour},
  journal={Annals of Pharmacotherapy},
  year={2013},
  volume={47},
  pages={63 - 74}
}
BACKGROUND The American Academy of Orthopaedic Surgeons (AAOS) and the American College of Chest Physicians (ACCP) have both developed evidence-based guidelines to prevent venous thromboembolism (VTE) in high-risk orthopedic surgery patients. Recent changes to these documents have brought them into agreement as to the inclusion of aspirin as an appropriate option for VTE prophylaxis in this patient population. OBJECTIVE To evaluate the appropriateness of aspirin to prevent VTE in high-risk… 
Aspirin for prevention of venous thromboembolism in recipients of major lower-limb orthopaedic surgery: a systematic review of level I evidence.
TLDR
Aspirin may be a viable alternative to established thromboprophylactic regimes for primary prevention of VTE, however in the setting of secondary prevention it is generally less efficacious.
A systematic review on the effect of aspirin in the prevention of post-operative arterial thrombosis in patients undergoing total hip and total knee arthroplasty.
TLDR
It is uncertain whether aspirin is effective in reducing the incidence of postoperative AT, and the results do emphasize the need for developing specifically designed studies to test the safety and efficacy of ASA in the prevention of post-operative AT.
Evaluation of Pharmacologic Strategies for Prevention of Venous Thromboembolism in Elective Orthopedic Surgery
Background: Venous thromboembolism (VTE) is a common postoperative complication in orthopedic surgery and warrants the use of pharmacologic thromboprophylaxis. The purpose of this study was to
Review of Therapeutic Options for the Prevention of VTE in Total Joint Arthroplasty
TLDR
Current literature supports the use of oral aspirin regimens in place of more aggressive anticoagulants, particularly among low risk patients, and available evidence does not demonstrate clear superiority among current options, all of which may place patients at a higher risk of bleeding and wound complications.
The risk of venous thromboembolism with aspirin compared to anticoagulants after hip and knee arthroplasty.
TLDR
Aspirin was uncommonly administered as the sole prophylactic agent after hip or knee arthroplasty in this study, and patients who received aspirin-only had similar rates of post-operative VTE compared to patientsWho received anticoagulants.
Thromboembolism prophylaxis failure rates after hip and knee arthroplasty: comparison of aspirin and anticoagulants
TLDR
It is suggested that there is no difference between the efficacy of aspirin and anticoagulants for VTE prophylaxis after total hip or total knee arthroplasty.
Aspirin versus anticoagulation for prevention of venous thromboembolism major lower extremity orthopedic surgery: a systematic review and meta-analysis.
TLDR
Compared with anticoagulation, aspirin may be associated with higher risk of DVT following hip fracture repair, although bleeding rates were substantially lower, and aspirin was similarly effective after lower extremity arthroplasty and may beassociated with lower bleeding risk.
Current approaches to prevention of venous thromboembolism following major orthopaedic surgery: a review of recommendations by international guidelines
TLDR
The current approaches being used to reduce post hip and knee replacement incidences of VTE as recommended by various external guidelines are reviewed for benchmarking purposes in the Kenyan context.
Aspirin Compared with Anticoagulation to Prevent Venous Thromboembolism After Knee or Hip Arthroplasty: a Large Retrospective Cohort Study
TLDR
Postoperative thromboprophylaxis with aspirin-only was not associated with a higher risk of postoperative venous thromboembolism compared with anticoagulants after hip or knee arthroplasty.
Aspirin for Prophylaxis Against Venous Thromboembolism After Orthopaedic Oncologic Surgery
TLDR
Aspirin may be a suitable and effective option for VTE chemoprophylaxis in patients treated with orthopaedic oncologic surgery, especially those diagnosed with a soft-tissue sarcoma.
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