Aspirin for dual prevention of venous and arterial thrombosis.

  title={Aspirin for dual prevention of venous and arterial thrombosis.},
  author={Theodore E Warkentin},
  journal={The New England journal of medicine},
  volume={367 21},
Aspirin is conventionally regarded as an agent that prevents arterial thrombosis, an effect mediated through inhibition of platelet cyclooxygenase-1, resulting in decreased synthesis of thromboxane A2 (platelet-activating eicosanoid). In high-risk patients, aspirin reduces by one quarter the frequency of arterial thrombosis.1 In 1977, aspirin (at a dose of 600 mg twice daily) was shown to reduce the risk of venous thrombosis when it was given to patients after they had undergone hip arthoplasty… CONTINUE READING
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