Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.

@article{Mattiello2011AspirinEF,
  title={Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.},
  author={Teresa Mattiello and Raffaella Guerriero and Lavinia Vittoria Lotti and Elisabetta Trifir{\`o} and Maria Pia Felli and Alessandro Barbarulo and Bruna Pucci and Paola Gazzaniga and Carlo Gaudio and Luigi Frati and Fabio Maria Pulcinelli},
  journal={Journal of the American College of Cardiology},
  year={2011},
  volume={58 7},
  pages={752-61}
}
OBJECTIVES In this study we investigate: 1) the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating aspirin action on human platelet cyclooxygenase (COX)-1; and 2) whether the impairment of aspirin-COX-1 interaction, found in coronary artery bypass grafting (CABG) patients, could be dependent on MRP4-mediated transport. BACKGROUND Platelets of CABG patients present a reduced sensitivity to aspirin despite in vivo and in vitro drug… CONTINUE READING

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