Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms

  title={Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms},
  author={Whay Kuang Chia and Raghib Ali and Han Chong Toh},
  journal={Nature Reviews Clinical Oncology},
A high-quality body of evidence supports the use of aspirin in reducing sporadic and hereditary adenomatous polyps, and numerous observational studies point to a reduction in colorectal cancer (CRC) risk. However, using aspirin as an adjuvant therapy in established CRC was until recently inconceivable. Now, evidence from both observational and clinical trials of aspirin for other indications suggests that aspirin initiation after (or before) the diagnosis of CRC improves CRC-specific mortality… CONTINUE READING
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