Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx.

@article{Togo2009AspirinAS,
  title={Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx.},
  author={Kana Togo and Yoshihiro Suzuki and Tetsuro Yoshimaru and Toshio Inoue and Tadashi Terui and Toyoko Ochiai and Chisei Ra},
  journal={Clinical immunology},
  year={2009},
  volume={131 1},
  pages={145-56}
}
Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that may potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance. Aspirin intolerance is accompanied by increased leukotriene (LT) synthesis, and high levels of serum IgE are a risk factor for NSAID sensitivity. Here we demonstrate that aspirin modulates LTC(4) secretion in mast cells. Therapeutic levels of aspirin and salicylates (<or=0.3 mM, i.e., the… CONTINUE READING