Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis.

@article{Schroer1997AspirinAP,
  title={Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis.},
  author={Karsten Schroer},
  journal={Seminars in thrombosis and hemostasis},
  year={1997},
  volume={23 4},
  pages={349-56}
}
The antithrombotic action of aspirin (acetylsalicylic acid) is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase (COX) at the functionally important amino acid serine529. This prevents the access of the substrate (arachidonic aid) to the catalytic site of the enzyme at tyrosine385 and results in an irreversible inhibition of platelet-dependent thromboxane formation. Aspirin is an approximately 150- to 200-fold more potent inhibitor of the (constitutive… CONTINUE READING
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