Aspirin and Reye Syndrome

  title={Aspirin and Reye Syndrome},
  author={Karsten Schr{\"o}r},
  journal={Pediatric Drugs},
  • K. Schrör
  • Published 2007
  • Medicine, Biology
  • Pediatric Drugs
Reye syndrome is an extremely rare but severe and often fatal disease. Death occurs in about 30–40% of cases from brainstem dysfunction. The disease typically is preceded by a viral infection with an intermediate disease-free interval of 3–5 days. The biochemical explanation for Reye-like symptoms is a generalized disturbance in mitochondrial metabolism, eventually resulting in metabolic failure in the liver and other tissues.The etiology of ‘classical’ Reye syndrome is unknown. Hypothetically… 

Reye's and Reye's‐like syndromes

The review reports various questions about Reye's syndrome and Reye’s‐like syndromes, and a full discussion of biochemical mechanisms of salicylate‐induced Rey's syndrome is reported.

Aspirin rechallenge in an adult patient previously diagnosed with Reye syndrome.

  • BrookeAnne MagrumK. Pickworth
  • Medicine, Biology
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2019
This, to the authors' knowledge, appears to be the first report of a low-dose aspirin rechallenge 30 years later in life in an adult patient with a history of Reye syndrome while receiving aspirin therapy during childhood.

FPIN's Clinical Inquiries. Aspirin use in children for fever or viral syndromes.

Aspirin use in children younger than 19 years should be limited to diseases in which aspirin has a proven benefit, such as Kawasaki disease and the juvenile arthritides.

Clinical Presentation, Treatment and Prognosis in Children with Reye-like Syndrome Reye-like Sendromu Olan Çocuklarda Klinik Prezentasyon, Tedavi ve Prognoz

Rye like syndrome occurs only rarely but should be a part of the differential diagnosis of any encephalopathy of unknown origin and above all if there is a history of ingestion of drugs, previous viral infection and vomiting.

Case Report: MIS-C Temporarily Associated With COVID-19 Complicated by Reye's Syndrome

A 7-year-old child was temporarily associated with the novel coronavirus disease which evolved into serious illness, with coronary aneurysm, using human immunoglobulin and acetylsalicylic acid, in which clinical manifestations including hepatitis, convulsions, and coma were aggravated with Reye's syndrome.

Management of acute mitochondriopathy and encephalopathy syndrome in pediatric intensive care unite: a new clinical entity

AMES occurs rarely, but should be kept in mind in the differential diagnosis of patients with any encephalopathy of unknown origin especially in those with a history of ingestion of drugs, previous viral infection and vomiting.

Fatal case of Reye's syndrome associated with H3N2 influenza virus infection and salicylate intake in a 12-year-old patient.

  • L. NinoveL. Daniel R. Charrel
  • Medicine
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2011
In the current situation of the novel A/H1N1 virus pandemic, it is of high importance to emphasize the risks associated with salicylate intake to avoid the reappearance of Reye's syndrome.

Influenza-associated central nervous system dysfunction: a literature review.

  • S. Toovey
  • Medicine, Psychology
    Travel medicine and infectious disease
  • 2008



Reye syndrome—insights on causation and prognosis

The evidence on prodromal aspirin and RS has been reviewed and several case–control studies assert that the association is strong, consistent, and unbiased.

Reye's syndrome and aspirin.

There can now be no reasonable doubt that aspirin given to a child infected with chickenpox or influenza increases his or her risk of developing Reye's syndrome, and paediatric prescriptions for aspirin should be more careful.

Reye's syndrome and aspirin: lest we forget

A boy aged 12.5 years had flu-like symptoms of mild fever, headache, and generalised aches for five days, after which his symptoms seemed to resolve, but 12 hours later he began vomiting, and this continued almost hourly for 24 hours, at which time his parents sought medical help.

Is Aspirin a Cause of Reye’s Syndrome?

It is clear from epidemiological data that the incidence of Reye’s syndrome was decreasing well before warning labels were placed on aspirin products, and it is probably either a viral mutation which spontaneously disappeared, or a conglomeration of metabolic disorders that had not been recognized or described at that time.

Reye's Syndrome and Aspirin: A Review

  • S. Hall
  • Medicine
    British journal of clinical practice. Supplement
  • 1990
The epidemiology of RS in Britain is similar to that in theUSA in two respects-an equal sex distribution and a significant excess of cases living in rural areas there are important differences: the median age, 14 months, is younger; the mortality at 50% is higher; and there is no clear, strong association with influenza but rather with a wide variety of viruses.

Reye's and Reye-like syndromes, drug-related diseases? (causative agents, etiology, pathogenesis, and therapeutic approaches).

It is suggested that the generalized damage and encephalopathy seen in both RS and RLS may be due to a wide variety of causative agents that contribute to a common derangement, principally involving mitochondrial oxidative pathway.

Reye's syndrome: Current concepts

What factors (NH3, free fatty acids and dicarboxylic acids) may be implicated in the pathogenesis of the CNS disease with the hopes of devising strategies for more effective treatment of encephalopathy and its attendant morbidity and mortality should be delineated.

Reye syndrome revisited: a descriptive term covering a group of heterogeneous disorders

A detailed analysis of the epidemiological surveys of the Centers for Disease Control, the Yale study and of the British risk factor study provides evidence that not only the use of acetylsalicylic acid but also that of phenothiazines and other anti-emetics is significantly greater in Reye syndrome cases than in controls.

Reye syndrome or side-effects of anti-emetics?

By analysing two patients initially diagnosed as Reye syndrome evidence is given that in some patients considered as having Reye syndrome, the syndrome is an escalation of symptoms due to viral

Reye's syndrome revisited

The paper is surprised that McGovern et al ignore the misleading biases in the epidemiological studies suggesting a link between Reye's syndrome and aspirin, and suggests that the estimates of the occurrence of paracetamol toxicity are the tip of the iceberg of the total number of cases seen in the United States.