Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion

  title={Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion},
  author={Niamh M. Cooke and Cathy D. Spillane and Orla M. Sheils and John W. O’Leary and Dermot Kenny},
  booktitle={BMC Cancer},
Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level. Cell lines 59 M and SK-OV-3 were used as in vitro model… CONTINUE READING
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