Aspirin Resistance in Single-Ventricle Physiology: Aspirin Prophylaxis Is Not Adequate to Inhibit Platelets in the Immediate Postoperative Period.

@article{Mir2015AspirinRI,
  title={Aspirin Resistance in Single-Ventricle Physiology: Aspirin Prophylaxis Is Not Adequate to Inhibit Platelets in the Immediate Postoperative Period.},
  author={Arshid Mir and Summer G Frank and Janna M. Journeycake and Joshua Wolovitis and Kristine J. Guleserian and Lisa C. Heistein and Matthew S. Lemler},
  journal={The Annals of thoracic surgery},
  year={2015},
  volume={99 6},
  pages={
          2158-64
        }
}
BACKGROUND Incidence of thrombosis after initial stage 1 single-ventricle palliation is high. Most centers use aspirin as an antiplatelet agent to prevent thrombosis in surgically placed shunts. We hypothesize there is a significant incidence of aspirin resistance in infants after stage 1 palliation and this resistance can be overcome by an increased aspirin dose. METHODS This is a prospective observational study of 20 patients with single-ventricle physiology who required single-ventricle… CONTINUE READING
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