Aspirin Protects Dopaminergic Neurons Against Lipopolysaccharide-Induced Neurotoxicity in Primary Midbrain Cultures

@article{Wang2011AspirinPD,
  title={Aspirin Protects Dopaminergic Neurons Against Lipopolysaccharide-Induced Neurotoxicity in Primary Midbrain Cultures},
  author={Fang Wang and Heng Zhai and Luqi Huang and Hui Li and Yan M. Xu and Xian Qiao and Sheng-gang Sun and Yan Wu},
  journal={Journal of Molecular Neuroscience},
  year={2011},
  volume={46},
  pages={153-161}
}
Aspirin (ASA) is one of the most widely used nonsteroidal anti-inflammatory drugs. ASA has primarily been used to treat headaches, rheumatic pain, and inflammation, but its therapeutic effects have recently been demonstrated on a range of disorders, including those of the central nervous system. In this study, we investigated whether ASA is neuroprotective in inflammation-mediated neurodegenerative diseases. Pretreatment with ASA reduced the lipopolysaccharide (LPS)-induced degeneration of… CONTINUE READING

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