Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer

@article{Apostolova2014AsphericityOP,
  title={Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer},
  author={Ivayla Apostolova and Ingo Guenter Steffen and Florian Wedel and A. Lougovski and Simone Marnitz and Thorsten Derlin and Holger Amthauer and Ralph Buchert and Frank Hofheinz and Winfried Brenner},
  journal={European Radiology},
  year={2014},
  volume={24},
  pages={2077-2087}
}
To propose a novel measure, namely the ‘asphericity’ (ASP), of spatial irregularity of FDG uptake in the primary tumour as a prognostic marker in head-and-neck cancer. PET/CT was performed in 52 patients (first presentation, n = 36; recurrence, n = 16). The primary tumour was segmented based on thresholding at the volume-reproducible intensity threshold after subtraction of the local background. ASP was used to characterise the deviation of the tumour’s shape from sphere symmetry. Tumour stage… CONTINUE READING
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