Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.

@article{Sakuno2005AspergillusPC,
  title={Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.},
  author={Emi Sakuno and Ying Wen and Hidemi Hatabayashi and Hatsue Arai and Chiemi Aoki and Kimiko Yabe and Hiromitsu Nakajima},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 6},
  pages={
          2999-3006
        }
}
In the aflatoxin biosynthetic pathway, 5'-oxoaverantin (OAVN) cyclase, the cytosolic enzyme, catalyzes the reaction from OAVN to (2'S,5'S)-averufin (AVR) (E. Sakuno, K. Yabe, and H. Nakajima, Appl. Environ. Microbiol. 69:6418-6426, 2003). Interestingly, the N-terminal 25-amino-acid sequence of OAVN cyclase completely matched an internal sequence of the versiconal (VHOH) cyclase that was deduced from its gene (vbs). The purified OAVN cyclase also catalyzed the reaction from VHOH to versicolorin… CONTINUE READING
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