Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells.

  title={Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells.},
  author={Mithun Das Gupta and Mirjam Fliesser and James W. Springer and Tanja Breitschopf and Hannes Schlossnagel and Alicia P. Schmitt and Oliver Kurzai and Kerstin Huenniger and Hermann Einsele and Juergen Loeffler},
  journal={International journal of medical microbiology : IJMM},
  volume={304 5-6},
Aspergillus fumigatus is responsible for severe and often fatal infections in immunocompromised patients. The human immune response against this pathogenic mould is still not fully understood. Recently, microRNAs (miRNAs) have been characterized as regulators of inflammation and immune response in various diseases. MiRNAs specifically bind to mRNA target sequences, thereby leading to gene silencing by target degradation and/or translational repression. To investigate the possible role of miRNAs… CONTINUE READING
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