Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins

@article{Arruda1990AspergillusFA,
  title={Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins},
  author={Luisa Karla de Paula Arruda and Thomas A. E. Platts-Mills and J. Wesley Fox and Martin D. Chapman},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={1529 - 1532}
}
A major 18-kD IgE-binding protein from Aspergillus fumigatus (Asp fI) has been purified. Partial amino acid sequencing of Asp f I showed extensive sequence homology (95%) between Asp fI and a cytotoxin (mitogillin) produced by A. restrictus. Crossinhibition radioimmunoassay using murine monoclonal antibody and human IgG and IgE antibodies showed that Asp fI and mitogillin were antigenically indistinguishable. Furthermore, both proteins inhibited protein synthesis in vitro by greater than 90… CONTINUE READING
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