Aspergillus fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae.

Abstract

Conidial pigment biosynthesis is an important virulence factor in Aspergillus fumigatus, a human fungal pathogen. Involvement of DHN-melanin pathway in the biosynthesis of A. fumigatus conidial pigment implies that the Alb1p polyketide synthase (PKS) is a 1,3,6, 8-tetrahydroxynaphthalene (T4HN) synthase. The Alb1p, however, shows higher sequence similarity… (More)

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