Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds.

  title={Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds.},
  author={Cornelia Speth and Magdalena Hagleitner and Helmut Werner Ott and Reinhard Wuerzner and Lass-Fl{\"o}rl Cornelia and G{\"u}nter Rambach},
  journal={The Journal of infectious diseases},
  volume={207 5},
During invasive aspergillosis, platelets might be involved in immune defense, but they also might contribute to the pathology of the disease. We tested the hypothesis that Aspergillus secretes factors that influence the activity and functionality of thrombocytes. Platelets were incubated with medium wherein Aspergillus fumigatus was grown. This fungal culture supernatant potently stimulated thrombocytes in a time- and dose-dependent fashion, inducing release of alpha and dense granules… CONTINUE READING

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