Aspergillus conidia activate the complement by the mannan-binding lectin C2 bypass mechanism.

@article{Dumestreperard2008AspergillusCA,
  title={Aspergillus conidia activate the complement by the mannan-binding lectin C2 bypass mechanism.},
  author={C Dumestre-perard and Bertrand Lamy and Delphine Aldebert and Catherine Lemaire-Vieille and Ren{\'e}e Grillot and J P Brion and Jean Gagnon and J. -Y. Cesbron},
  journal={Journal of immunology},
  year={2008},
  volume={181 10},
  pages={7100-5}
}
Innate immunity is the major host defense against invasive aspergillosis. To determine whether the collectin mannan-binding lectin (MBL) is involved in the initial protective immunity through complement activation against opportunistic fungal infections caused by Aspergillus, we performed in vitro studies on 29 different strains of Aspergillus conidia from five different species. Incubation of Aspergillus conidia in human normal serum leads to activation of the alternative pathway, whereas… CONTINUE READING
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