Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence.

@article{Manfiolli2017AspergillusFP,
  title={Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence.},
  author={Adriana Oliveira Manfiolli and Patr{\'i}cia Alves de Castro and Thaila Fernanda Dos Reis and Stephen K. Dolan and Sean Doyle and Gary W. Jones and Diego M Ria{\~n}o Pach{\'o}n and Mevl{\"u}t Ulaş and Luke M Noble and Derek Joseph Mattern and Axel A. Brakhage and Vito Valiante and Rafael Silva-Rocha and Ozgur Bayram and Gustavo Henrique Goldman},
  journal={Cellular microbiology},
  year={2017},
  volume={19 12}
}
Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are essential for organism survival due to its involvement in several biological processes. Aspergillus fumigatus causes invasive aspergillosis, a disease that typically manifests in immunocompromised patients. A. fumigatus PpzA, the catalytic subunit of protein phosphatase Z (PPZ), has been recently identified as associated with iron assimilation… CONTINUE READING
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