Aspects of structural landscape of human islet amyloid polypeptide.

  title={Aspects of structural landscape of human islet amyloid polypeptide.},
  author={Jianfeng He and Jin Dai and Jing Li and Xu-biao Peng and Antti J. Niemi},
  journal={The Journal of chemical physics},
  volume={142 4},
The human islet amyloid polypeptide (hIAPP) co-operates with insulin to maintain glycemic balance. It also constitutes the amyloid plaques that aggregate in the pancreas of type-II diabetic patients. We have performed extensive in silico investigations to analyse the structural landscape of monomeric hIAPP, which is presumed to be intrinsically disordered. For this, we construct from first principles a highly predictive energy function that describes a monomeric hIAPP observed in a nuclear… 

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