Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations

@article{Wendum2012AspectsOL,
  title={Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations},
  author={Dominique Wendum and V{\'e}ronique Barbu and Olivier Rosmorduc and Lionel Arriv{\'e} and J. -F. Flejou and Raoul Poupon},
  journal={Virchows Archiv},
  year={2012},
  volume={460},
  pages={291-298}
}
The aims of this study were to describe the histological liver lesions in adult patients with MDR3/ ABCB4 mutation and to study the usefulness of MDR3 immunostaining as a diagnostic tool. All adult patients from our institution with an MDR3/ABCB4 mutation and a liver histology were included (n = 13). Eleven patients had a single heterozygous gene mutation and two patients had two heterozygous mutations. Two patients had no liver lesions. Eight patients had a mild ductular reaction and portal… CONTINUE READING
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