Aspects of influx and efflux of homovanillic acid of rat cerebrospinal fluid

@article{Aizenstein1978AspectsOI,
  title={Aspects of influx and efflux of homovanillic acid of rat cerebrospinal fluid},
  author={Moacyr Luiz Aizenstein and J. Korf},
  journal={Brain Research},
  year={1978},
  volume={149},
  pages={129-140}
}
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ASPECTS OF INFLUX AND EFFLUX OF BIOGENIC AMINE METABOLITES OF RAT CEREBROSPINAL FLUID
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A model by which the transvascular removal of unnecessary substances in brain edema fluid could be measured quantitatively and chronologically and found this efflux mechanism seems to be a rather stable protective process, and seems to play a considerable role in brain microenvironmental homeostasis.
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Reduced blood flow to periventricular white matter and impaired molecular clearance in the caudate nucleus may contribute to the clinical symptoms in acute hydrocephalus.
Measurement of metabolites of dopamine and 5-hydroxytryptamine in cerebroventricular perfusates of unanesthetized, freely-moving rats: Selective effects of drugs
HOMOVANILLIC ACID IN CEREBROSPINAL FLUID AND CARBON-11 LABELLED DOPA FOR THE DETECTION OF CEREBRAL DOPAMINE PROCESSES IN VIVO
Value of monoamine metabolite determinations in CSF as an index of their concentrations in rat brain following various pharmacological manipulations.
Cerebrospinal fluid (CSF) and brain monoamine metabolites in the developing rat pup.
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References

SHOWING 1-10 OF 20 REFERENCES
Homovanillic acid: entry rate kinetics for transfer from plasma to cerebrospinal fluid.
Homovanillic acid transport by the spinal cord
TLDR
The data show that homovanillic acid is transported by capillaries throughout spinal tissue by a mechanism largely insensitive to inhibition by probenecid, and therefore reflects only part of the total dopamine metabolism.
Intravenous probenecid loading
TLDR
In patients with either Huntington's chorea or Parkinson's disease, the intravenous infusion technique produced more consistent elevations in plasma and cerebrospinal fluid probenecid levels, greater increases in cerebro Spinal fluid homovanillic acid values, and fewer gastrointestinal side effects.
Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.
Turnover of acid dopamine metabolites in striatal and mesolimbic tissue of the rat brain.
Regional rat brain levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorometric measurement and influence of drugs.
Determination of nanogram amounts of homovanillic acid in the central nervous system with a rapid semiautomated fluorometric method.
HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD
TLDR
Treatment with probenecid either intraperitoneally or intrathecally did not alter the rate of release into CSF of these metabolites by the spinal cord but did significantly increase the rate-of- appearance in the cisterna magna of HVA originating from the brain.
On the significance of regional dopamine metabolism in the rat brain for the classification of centrally acting drugs.
Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies.
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