Aspects of influx and efflux of homovanillic acid of rat cerebrospinal fluid

@article{Aizenstein1978AspectsOI,
  title={Aspects of influx and efflux of homovanillic acid of rat cerebrospinal fluid},
  author={Moacyr Luiz Aizenstein and J. Korf},
  journal={Brain Research},
  year={1978},
  volume={149},
  pages={129-140}
}
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Homovanillic acid transport by the spinal cord
TLDR
The data show that homovanillic acid is transported by capillaries throughout spinal tissue by a mechanism largely insensitive to inhibition by probenecid, and therefore reflects only part of the total dopamine metabolism.
Intravenous probenecid loading
TLDR
In patients with either Huntington's chorea or Parkinson's disease, the intravenous infusion technique produced more consistent elevations in plasma and cerebrospinal fluid probenecid levels, greater increases in cerebro Spinal fluid homovanillic acid values, and fewer gastrointestinal side effects.
HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD
TLDR
Treatment with probenecid either intraperitoneally or intrathecally did not alter the rate of release into CSF of these metabolites by the spinal cord but did significantly increase the rate-of- appearance in the cisterna magna of HVA originating from the brain.
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