Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders

Abstract

Detrimental effects on the thyroid of the developing fetus as a result of iodine-131 treatment for thyrotoxicosis of the mother in the first trimester of pregnancy are discussed. Dose estimations under typical clinical circumstances yield a fetal thyroid dose of 100– 450 Sv. This dose may increase considerably if the blood concentration of 131I in the mother remains high. Under such circumstances there may be fetal thyroid dysfunction, which can lead to severe abnormalities.

DOI: 10.1007/s002590050478

Cite this paper

@article{Pauwels1999AspectsOF, title={Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders}, author={E. K. J. Pauwels and William H. Thomson and Jacobus A. K. Blokland and Mary E Schmidt and Michel H. Bourguignon and Tarek Abdel-Fattah El-Maghraby and Johan J. Broerse and Leslie K Harding}, journal={European Journal of Nuclear Medicine}, year={1999}, volume={26}, pages={1453-1457} }