Aspects of database construction and interrogation of relevance to the accurate prediction of rodent carcinogenicity and mutagenicity.

  • John Ashby
  • Published 1991 in Environmental health perspectives

Abstract

Attempts to reconcile qualitative carcinogenicity databases with qualitative mutagenicity database continue to indicate that there is no useful relationship between mutagenicity/genotoxicity and rodent carcinogenicity. It is suggested that recognition of two classes of carcinogen, genotoxic and nongenotoxic, is the first step in finding meaningful… (More)

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