Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.

@article{Kirmani2002AspartoacylaseIR,
  title={Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease.},
  author={Batool F Kirmani and David M. Jacobowitz and Abraham T. Kallarakal and M. A. Aryan Namboodiri},
  journal={Brain research. Molecular brain research},
  year={2002},
  volume={107 2},
  pages={176-82}
}
Canavan disease is a devastating neurodegenerative childhood disease caused by mutations in aspartoacylase, an enzyme that deacetylates N-acetylaspartate to generate free acetate in the brain. Localization of aspartoacylase in different cell types in the rat brain was examined in an attempt to understand the pathogenesis of Canavan disease. In situ hybridization histochemistry with a riboprobe based on murine aspartoacylase cDNA was used in this study. The hybridization signal was detectable… CONTINUE READING