Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins.

@article{Hughes2003AsparticPP,
  title={Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins.},
  author={Austin L. Hughes and Jonathan A. Green and Helen Piontkivska and R Michael Roberts},
  journal={Molecular biology and evolution},
  year={2003},
  volume={20 11},
  pages={1940-5}
}
The phylogenetic relationships of eukaryotic aspartic proteinases were reconstructed in order to understand the origin of pregnancy-associated glycoproteins (PAGs), which constitute a large gene family expressed in the trophoblast and placenta of mammals in the order Artiodactyla. The phylogeny supported the hypothesis that PAGs originated in mammals, being most closely related to a group of PAG-like molecules (including rodent pepsin F) found in other mammalian orders. These two groups in turn… CONTINUE READING