Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

@article{Coombs2001AsparticPO,
  title={Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.},
  author={Graham H. Coombs and David E. Goldberg and Michael Klemba and Colin Berry and John Kay and Jeremy C Mottram},
  journal={Trends in parasitology},
  year={2001},
  volume={17 11},
  pages={532-7}
}
All parasitic protozoa contain multiple proteases, some of which are attracting attention as drug targets. Aspartic proteases are already the targets of some clinically useful drugs (e.g. chemotherapy of HIV infection) and a variety of factors make these enzymes appealing to those seeking novel antiparasite therapies. This review provides a critical analysis of the current knowledge on Plasmodium aspartic proteases termed plasmepsins, proposes a definitive nomenclature for this group of enzymes… CONTINUE READING

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