Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation

Abstract

Post-translational influences could underlie the ambiguous roles of monoamine oxidase-A (MAO-A) in pathologies such as depression, cancer and Alzheimer disease. In support of this, we recently demonstrated that the Ca2+-sensitive component of MAO-A catalytic activity is inhibited by a pro-survival p38 (MAPK)-dependent mechanism. We substituted three… (More)
DOI: 10.1007/s00702-012-0779-x

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@article{Wei2012AsparticAS, title={Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation}, author={Zelan Wei and Tamara Satram-Maharaj and Bradley M Chaharyn and Kelly Kuski and Paul R. Pennington and Xia Cao and Jennifer Chlan and Darrell D. Mousseau}, journal={Journal of Neural Transmission}, year={2012}, volume={119}, pages={1285-1294} }