Aspartic acid-based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluation.

@article{Fu2014AsparticAM,
  title={Aspartic acid-based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluation.},
  author={Y. C. Fu and T F Fu and Hung Jen Wang and Che-Wei Lin and Gang-Hui Lee and Shun-Cheng Wu and Chih-Kuang Wang},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 11},
  pages={4583-4596}
}
Nanoparticles (NP) that target bone tissue were developed using PLGA-PEG (poly(lactic-co-glycolic acid)-polyethylene glycol) diblock copolymers and bone-targeting moieties based on aspartic acid, (Asp)(n(1,3)). These NP are expected to enable the transport of hydrophobic drugs. The molecular structures were examined by (1)H NMR or identified using mass spectrometry and Fourier transform infrared (FT-IR) spectra. The NP were prepared using the water miscible solvent displacement method, and… CONTINUE READING
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