Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.

@article{Fleck1993AspartateAG,
  title={Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.},
  author={Mark W. Fleck and Darrell A. Henze and Germ{\'a}n Barrionuevo and Alan M. Palmer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1993},
  volume={13 9},
  pages={3944-55}
}
We examined whether L-aspartate (ASP) and L-glutamate (GLU) both function as endogenous neurotransmitters in area CA1 of the rat hippocampus. Radioligand displacement experiments using 3H-DL-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (3H-AMPA) to label AMPA/kainate receptors and 3H-cis-4-phosphonomethyl-2-piperidine carboxylic acid (3H-CGS-19755) to label NMDA receptors confirmed that GLU (Ki approximately 500 nM) but not ASP (Ki > 1 mM) has high affinity for AMPA/kainate… CONTINUE READING
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