Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells.

@article{Aslanian2001AsparagineSE,
  title={Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells.},
  author={Ara M. Aslanian and Bradley S. Fletcher and Michael S. Kilberg},
  journal={The Biochemical journal},
  year={2001},
  volume={357 Pt 1},
  pages={321-8}
}
Childhood acute lymphoblastic leukaemia (ALL) is treated by combination chemotherapy with a number of drugs, always including the enzyme L-asparaginase (ASNase). Although the initial remission rate is quite high, relapse and associated drug resistance are a significant problem. In vitro studies have demonstrated increased asparagine synthetase (AS) expression in ASNase-resistant cells, which has led to the hypothesis that elevated AS activity permits drug-resistant survival. The data presented… CONTINUE READING

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