Asparagine synthetase: regulation by cell stress and involvement in tumor biology.


Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. The enzyme is ubiquitous in its organ distribution in mammals, but basal expression is relatively low in tissues other than the exocrine pancreas. Human ASNS activity is highly regulated in response to cell stress… (More)
DOI: 10.1152/ajpendo.00015.2013


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