Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) Inhibits High Glucose-Induced Inflammation In Vitro and In Vivo

@article{Ku2014AspalathinAN,
  title={Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) Inhibits High Glucose-Induced Inflammation In Vitro and In Vivo},
  author={Sae-Kwang Ku and Soyoung Kwak and Yaesol Kim and Jong-Sup Bae},
  journal={Inflammation},
  year={2014},
  volume={38},
  pages={445-455}
}
  • S. Ku, S. Kwak, J. Bae
  • Published 1 February 2015
  • Biology, Medicine, Chemistry
  • Inflammation
Vascular inflammation plays a key role in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Aspalathin (Asp) and nothofagin (Not) are two major active dihydrochalcones found in green rooibos, which have been reported for their antioxidant activity. In this study, we assessed whether Asp or Not can suppress vascular inflammation induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. We monitored the effects of Asp or… 
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